Impaired synapse elimination during cerebellar development in PKCγ mutant mice
نویسندگان
چکیده
Masanobu Kano, l Kouichi Hashimoto,’ Chong Chen,t Asa Abeliovich,t Atsu Aiba,t Hideo Kurihara,t Masahiko Watanabe,* Yoshiro Inoue,* and Susumu Tonegawat *Department of Physiology Jichi Medical School Minamikawachi-machi Tochigi-ken 329-04 Japan tHoward Hughes Medical Institute Center for Learning and Memory Center for Cancer Research and Department of Biology Massachusetts Institute of Technology Cambridge, Massachusetts 02139 *Department of Anatomy Hokkaido University School of Medicine Sapporo 606 Japan
منابع مشابه
Mutant PKCγ in spinocerebellar ataxia type 14 disrupts synapse elimination and long-term depression in Purkinje cells in vivo.
Cerebellar Purkinje cells (PCs) express a large amount of the γ isoform of protein kinase C (PKCγ) and a modest level of PKCα. The PKCγ is involved in the pruning of climbing fiber (CF) synapses from developing PCs, and PKCα plays a critical role in long-term depression (LTD) at parallel fiber (PF)-PC synapses. Moreover, the PKC signaling in PCs negatively modulates the nonselective transient r...
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Climbing fiber (CF) synapse formation onto cerebellar Purkinje cells (PCs) is critically dependent on the synaptogenesis from parallel fibers (PFs), the other input to PCs. Previous studies revealed that deletion of the glutamate receptor delta2 subunit (GluRdelta2) gene results in persistent multiple CF innervation of PCs with impaired PF synaptogenesis, whereas mutation of the metabotropic gl...
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ورودعنوان ژورنال:
- Cell
دوره 83 شماره
صفحات -
تاریخ انتشار 1995